Imbalances in metal and oxidative stress in Alzheimer's disease

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

<<snip>>
**pathological** role of oxidative stress
<<snip>>

Ann Ist Super Sanita. 2005;41(2):143-64. Related Articles, Links

Metal ions and oxidative protein modification in neurological disease.

Sayre LM, Moreira PI, Smith MA, Perry G.

Department of Chemistry, Case Western Reserve University, Cleveland, OH
44106, USA. lms3@po.cwru.edu

This review highlights the role of oxidative stress and imbalances in
metal ion homeostasis in the neurodegenerative diseases Alzheimer's
disease and Parkinson's disease and in the progressive demyelinating
disease multiple sclerosis. The chemistry and biochemistry of oxidative
stress-induced protein damage are first described, followed by the
evidence for a pathological role of oxidative stress in these disease
states. It is tempting to speculate that free radical oxygen chemistry
contributes to pathogenesis in all these conditions, though it is as
yet undetermined what types of oxidative changes occur early in the
disease, and what types are secondary manifestations of neuronal
degeneration.

Publication Types:
Review

PMID: 16244388 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Google