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ironjustice@aol.com medicine forum Guru
Joined: 28 Apr 2005
Posts: 1522
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Posted: Fri Jun 16, 2006 3:02 pm Post subject:
Lactoferrin inhibits urinary tract infection
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Antiviral Res. 2006 Jun 2; [Epub ahead of print] Related Articles,
Links
Lactoferrin inhibits early steps of human BK polyomavirus infection.
Longhi G, Pietropaolo V, Mischitelli M, Longhi C, Conte MP, Marchetti
M, Tinari A, Valenti P, Degener AM, Seganti L, Superti F.
Department of Public Health Sciences, University of "La Sapienza",
Piazzale Aldo Moro, 5, 00185 Rome, Italy.
Lactoferrin, a member of the transferrin family, is a bi-globular iron
binding glycoprotein, found in milk, exocrine secretions of mammals,
and in secondary granules of polymorphonuclear neutrophiles that plays
an important role in the defence against various pathogenic
microorganisms. Previous studies in different virus-cell systems showed
that lactoferrin is a potent inhibitor of different enveloped and naked
virus infection. In this research we studied the effect of lactoferrin
on BK polyomavirus, a human naked double-stranded DNA virus responsible
for productive, persistent, and latent infections of the urinary tract.
Results obtained demonstrate that lactoferrin treatment prevents early
steps of BK virus infection in Vero cells, at the level of the
adsorption phase, probably through the interaction with capsidic
structures, although a lactoferrin-BK virus competition for cell
plasma-membrane receptors cannot be ruled out.
PMID: 16774792 [PubMed - as supplied by publisher]
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PeterB medicine forum Guru
Joined: 28 Apr 2005
Posts: 384
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Posted: Mon Jun 19, 2006 8:01 pm Post subject:
Re: Lactoferrin inhibits urinary tract infection
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ironjustice@aol.com wrote:
| Quote: | Antiviral Res. 2006 Jun 2; [Epub ahead of print] Related Articles,
Links
Lactoferrin inhibits early steps of human BK polyomavirus infection.
Longhi G, Pietropaolo V, Mischitelli M, Longhi C, Conte MP, Marchetti
M, Tinari A, Valenti P, Degener AM, Seganti L, Superti F.
Department of Public Health Sciences, University of "La Sapienza",
Piazzale Aldo Moro, 5, 00185 Rome, Italy.
Lactoferrin, a member of the transferrin family, is a bi-globular iron
binding glycoprotein, found in milk, exocrine secretions of mammals,
and in secondary granules of polymorphonuclear neutrophiles that plays
an important role in the defence against various pathogenic
microorganisms. Previous studies in different virus-cell systems showed
that lactoferrin is a potent inhibitor of different enveloped and naked
virus infection. In this research we studied the effect of lactoferrin
on BK polyomavirus, a human naked double-stranded DNA virus responsible
for productive, persistent, and latent infections of the urinary tract.
Results obtained demonstrate that lactoferrin treatment prevents early
steps of BK virus infection in Vero cells, at the level of the
adsorption phase, probably through the interaction with capsidic
structures, although a lactoferrin-BK virus competition for cell
plasma-membrane receptors cannot be ruled out.
PMID: 16774792 [PubMed - as supplied by publisher]
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Lactoferrin is a very interesting application in natural medicine. If
you have an intestinal virus, lactoferrin helps by binding with iron
that would otherwise have fed the virus. As for cell-loading iron, it
should be useful for drawing down iron stores over time, but I'm not
aware of research that documents such an effect, and it would be
ill-advised without professional guidance.
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