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Eli
medicine forum beginner
Joined: 13 Jul 2005
Posts: 5
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 Posted: Wed Jun 07, 2006 2:54 pm Post subject:
Chinese remedy 'treats diabetes'
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"A gardenia fruit extract used in Chinese medicine for centuries to
treat adult onset diabetes is effective, scientists have found."
http://news.bbc.co.uk/1/hi/health/5052212.stm |
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TC
medicine forum Guru
Joined: 02 May 2005
Posts: 1814
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| Posted: Wed Jun 07, 2006 3:37 pm Post subject:
Re: Chinese remedy 'treats diabetes'
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No One wrote:
You know, if we knew that diabetes occurred because of the absence of
this extract in the diet, then I might just believe that this would be
the correct treatment and a sure-fire cure. But somehow, I don't think
that that is the case.
TC |
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TC
medicine forum Guru
Joined: 02 May 2005
Posts: 1814
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| Posted: Wed Jun 07, 2006 5:51 pm Post subject:
Re: Chinese remedy 'treats diabetes'
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outsor@citynet.net wrote:
| Quote: | "You know, if we knew that diabetes occurred because of the absence of
this extract in the diet, then I might just believe that this would be the
correct treatment and a sure-fire cure. But somehow, I don't think that
that is the case.
You didn't read the article, go back and read it and see what process is
affected by the extract.
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"The US team found a chemical from the fruit blocks the action of an
enzyme which stops the production of insulin."
So it messes with the bodies natural ability to limit the production of
insulin.
It does nothing to remedy the reason why the body needs to produce
inordinate amounts of insulin, which is high blood sugar levels caused
by overconsumption of foods that inordinately increase blood sugar
levels ie. refined carbs.
Reduce the overconsumption of refined carbs and your blood sugar levels
will remain within normal ranges and the pancreas is not forced to
overproduce insulin.
It isn't the absence of this extract that caused the diabete t2 in the
first place, why the frig would we want to waste time with that crap.
Deal with the cause and resolve the disease. We do not need any more
"slightly better than a sugar pill" pretend treatments.
TC |
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Curious
medicine forum beginner
Joined: 05 Aug 2005
Posts: 5
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| Posted: Wed Jun 07, 2006 6:15 pm Post subject:
Re: Chinese remedy 'treats diabetes'
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No One wrote:
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity-
and high glucose-induced beta cell dysfunction in isolated pancreatic
islets.
Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr,
Lowell BB.
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess
Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston,
Massachusetts 02215; State Key Laboratory of Pharmaceutial
Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou
Road, Nanjing, Jiangsu, China.
Uncoupling protein 2 (UCP2) negatively regulates insulin secretion. UCP2
deficiency (by means of gene knockout) improves obesity- and high
glucose-induced beta cell dysfunction and consequently improves type 2
diabetes in mice. In the present study, we have discovered that the
small molecule, genipin, rapidly inhibits UCP2-mediated proton leak. In
isolated mitochondria, genipin inhibits UCP2-mediated proton leak. In
pancreatic islet cells, genipin increases mitochondrial membrane
potential, increases ATP levels, closes K(ATP) channels, and stimulates
insulin secretion. These actions of genipin occur in a UCP2-dependent
manner. Importantly, acute addition of genipin to isolated islets
reverses high glucose- and obesity-induced beta cell dysfunction. Thus,
genipin and/or chemically modified variants of genipin are useful
research tools for studying biological processes thought to be
controlled by UCP2. In addition, these agents represent lead compounds
that comprise a starting point for the development of therapies aimed at
treating beta cell dysfunction.
PMID: 16753577 [PubMed - as supplied by publisher]
--
I'll live forever or die trying |
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Olafur Pall Olafsson
medicine forum beginner
Joined: 14 Feb 2005
Posts: 20
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| Posted: Thu Jun 08, 2006 4:57 am Post subject:
Re: Chinese remedy 'treats diabetes'
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Curious wrote:
| Quote: | No One wrote:
"A gardenia fruit extract used in Chinese medicine for centuries to
treat adult onset diabetes is effective, scientists have found."
http://news.bbc.co.uk/1/hi/health/5052212.stm
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity-
and high glucose-induced beta cell dysfunction in isolated pancreatic
islets.
Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr,
Lowell BB.
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess
Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston,
Massachusetts 02215; State Key Laboratory of Pharmaceutial
Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou
Road, Nanjing, Jiangsu, China.
Uncoupling protein 2 (UCP2) negatively regulates insulin secretion. UCP2
deficiency (by means of gene knockout) improves obesity- and high
glucose-induced beta cell dysfunction and consequently improves type 2
diabetes in mice. In the present study, we have discovered that the
small molecule, genipin, rapidly inhibits UCP2-mediated proton leak. In
isolated mitochondria, genipin inhibits UCP2-mediated proton leak. In
pancreatic islet cells, genipin increases mitochondrial membrane
potential, increases ATP levels, closes K(ATP) channels, and stimulates
insulin secretion. These actions of genipin occur in a UCP2-dependent
manner. Importantly, acute addition of genipin to isolated islets
reverses high glucose- and obesity-induced beta cell dysfunction. Thus,
genipin and/or chemically modified variants of genipin are useful
research tools for studying biological processes thought to be
controlled by UCP2. In addition, these agents represent lead compounds
that comprise a starting point for the development of therapies aimed at
treating beta cell dysfunction.
PMID: 16753577 [PubMed - as supplied by publisher]
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The negative effects of elevated free fatty acids and oxidative stress
on beta cells also seems to depend on UCP2 expression:
J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23. Related
Articles, Links
Click here to read
Free fatty acid-induced beta-cell defects are dependent on
uncoupling protein 2 expression.
Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB,
Chan CB, Wheeler MB.
Departments of Medicine and Physiology, University of Toronto,
Ontario M5S 1A8, Canada.
Chronic exposure to elevated free fatty acids (lipotoxicity)
induces uncoupling protein (UCP2) in the pancreatic beta-cell, and
therefore a causal link between UCP2 and beta-cell defects associated
with obesity may exist. Recently, we showed that lipid treatment in
vivo and in vitro in UCP2(-/-) mice/islets does not result in any loss
in beta-cell glucose sensitivity. We have now assessed the mechanism of
maintained beta-cell function in UCP2(-/-) mice by exposing islets to
0.4 mM palmitate for 48 h. Palmitate treatment increased triglyceride
concentrations in wild type (WT) but not UCP2(-/-) islets because of
higher palmitate oxidation rates in the UCP2(-/-) islets. Dispersed
beta-cells from the palmitate-exposed WT islets had reduced
glucose-stimulated hyperpolarization of the mitochondrial membrane
potential compared with both control WT and palmitate-exposed UCP2(-/-)
beta-cells. The glucose-stimulated increases in the ATP/ADP ratio and
cytosolic Ca2+ are attenuated in palmitate-treated WT but not UCP2(-/-)
beta-cells. Exposure to palmitate reduced glucose-stimulated insulin
secretion (GSIS) in WT islets, whereas UCP2(-/-) islets had enhanced
GSIS. Overexpression of recombinant UCP2 but not enhanced green
fluorescent protein in beta-cells resulted in a loss of
glucose-stimulated hyperpolarization of the mitochondrial membrane
potential and GSIS similar to that seen in WT islets exposed to
palmitate. Reactive oxygen species (ROS) are known to increase the
activity of UCP2. We showed that ROS levels were elevated in control
UCP2(-/-) islets as compared with WT and UCP2(-/-) islets
overexpressing UCP2 and that palmitate increased ROS in WT and
UCP2(-/-) islets overexpressing UCP2 but not in UCP2(-/-) islets. Thus,
UCP2(-/-) islets resisted the toxic effects of palmitate by maintaining
glucose-dependent metabolism-secretion coupling. We propose that higher
free fatty acid oxidation rates prevent accumulation of triglyceride in
UCP2(-/-) islets, such accumulation being a phenomenon associated with
lipotoxicity.
PMID: 15448158 [PubMed - indexed for MEDLINE] |
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mattlb@angelfire.com
medicine forum beginner
Joined: 27 Feb 2006
Posts: 36
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| Posted: Thu Jun 08, 2006 9:40 am Post subject:
Re: Chinese remedy 'treats diabetes'
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outsor@citynet.net wrote:
| Quote: | Thank you for finally reading the article. Carb intake is also not the
cause of diabetes. While glucose intake limits can reverse many symptoms,
but not in all people, it is also not a cure for it either. On
reflecction, you can see your original remarks were not relevant to the
article, the present ones only slightly more so. The effective treatment
for diabetes is one which matches the available insulin production to
glucose intake
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That would certainly be true if all insulin did was lower blood
glucose, but it has a number of other actions, all of which are also
increased if high glucose intake leads to higher insulin secretion.
It's therefore better to reduce carb intake than chronically raise
insulin to compensate for chronic high carb intake.
MattLB |
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outsor@citynet.net
medicine forum Guru
Joined: 11 Sep 2005
Posts: 569
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| Posted: Thu Jun 08, 2006 12:43 pm Post subject:
Re: Chinese remedy 'treats diabetes'
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"It's therefore better to reduce carb intake than chronically raise
insulin to compensate for chronic high carb intake."
"Raising" is misleading, the body in non-diabetics raises insulin to
balance glucose levels. The word should be over compensate insulin
production. Normal control or that achieved by a diabetic is to balance
both glucose intake and insulin production. A diabetic is advised to work
on both sides of the equation for best control. If that means low carb
intake then so be it in the case where available insulin production is
low. The key is to find the technique that results in the least swings in
glucose. |
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