Appendicitis / oxidative stress

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

This would give credence to Dr. Sullivan's thirty year old observation
... iron stores are reflected .. many times .. by the appearance of
appendicitis.

Plasma total anti-oxidant capacity correlates inversely with the extent
of acute appendicitis: a case control study.
Ozdogan M, Devay AO, Gurer A, Ersoy E, Devay SD, Kulacoglu H, Gundogdu
H
World J Emerg Surg. 2006 Mar 24; 1(1): 6

ABSTRACT: BACKGROUND: The role of free oxygen radicals in inflammatory
conditions is well known. Free radicals cause lipid peroxidation of
cellular membranes resulting in cell death. The purpose of this study
was to investigate the levels of total anti-oxidant status (TAS), as a
marker of anti-oxidant defense system and malondialdehyde (MDA), as a
marker of oxidative stress, in the plasma of patients with acute
appendicitis. METHODS: Fifty-one adult patients with a median age of 31
years who underwent operations with a preoperative diagnosis of acute
appendicitis were included in this prospective study. Blood samples for
C-reactive protein (CRP), MDA and TAS were collected preoperatively.
Groups were compared by using the Mann-Whitney U test. RESULTS: There
were 27 patients with acute phlagmenous appendicitis and 19 patients
with advanced appendicitis (10 gangrenous and 9 perforated
appendicitis), while 5 negative explorations were documented. No
significant differences in WBC counts and MDA levels between groups
were encountered. Plasma CRP was significantly higher in patients with
perforated appendicitis, but not in the other groups. In advanced
appendicitis group, TAS level was significantly lower than the other
groups. On the other hand, plasma TAS level in acute phlagmenous
appendicitis group was significantly higher. CONCLUSION: A decrease in
plasma total anti-oxidant capacity might be a predictor of the
progression of inflammation to the perforation in acute appendicitis.

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babawali@world.com · medicine forum addict Joined: 29 Apr 2006 Posts: 81

"This would give credence to Dr. Sullivan's thirty year old observation
... iron stores are reflected .. many times .. by the appearance of
appendicitis.

Plasma total anti-oxidant capacity correlates inversely with the extent
of acute appendicitis: a case control study."

No, stored iron is bound iron which doesn't contribute to an antioxidant
process. One of the several flaws in the "iron causes all diseases"
notion.

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