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ironjustice@aol.com
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1522
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 Posted: Fri Jun 09, 2006 1:58 pm Post subject:
Tuberculosis / iron acquisition
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Control of iron metabolism in Mycobacterium tuberculosis.
Rodriguez GM
Trends Microbiol. 2006 Jun 4;
Tuberculosis continues to kill millions of people around the world. New
tools to prevent and treat this disease are urgently needed. Similar to
most microorganisms, Mycobacterium tuberculosis - the causative agent
of tuberculosis - requires iron for essential metabolic pathways.
Because iron is not freely available in the host, pathogens must
actively compete for this metal to establish an infection but they must
also carefully control iron acquisition as excess free iron can be
extremely toxic. Recent studies have demonstrated that failure to
assemble the iron acquisition machinery or to repress iron uptake has
deleterious effects for M. tuberculosis. Here, we review how M.
tuberculosis obtains iron in a regulated manner and discuss how these
processes could potentially be disrupted to interfere with the survival
and replication of this bacterium in the host.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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babawali@world.com
medicine forum addict
Joined: 29 Apr 2006
Posts: 81
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| Posted: Fri Jun 09, 2006 1:58 pm Post subject:
Re: Tuberculosis / iron acquisition
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"Because iron is not freely available in the host, pathogens must actively
compete for this metal to establish an infection but they must also
carefully control iron acquisition as excess free iron can be extremely
toxic. "
Yes, free iron not common in the body and too much free iron is toxic to
the tb bacteria. |
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ironjustice@aol.com
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1522
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| Posted: Sat Jun 10, 2006 5:42 am Post subject:
Re: Tuberculosis / iron acquisition
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babawali@world.com wrote:
| Quote: | "Because iron is not freely available in the host, pathogens must actively
compete for this metal to establish an infection but they must also
carefully control iron acquisition as excess free iron can be extremely
toxic. "
Yes, free iron not common in the body and too much free iron is toxic to
th
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Soooo .. one can .. 'do the study in your head' .. and say .. "it seems
we probably ARE .. killing .. millions of kids by the routine
supplementation of iron in their foods .. just like we have been doing
in those kids with malaria. We've been killing them by the millions ..
too .. " ..
Or .. are you .. stupid ..
Take .. your .. pick ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
e tb bacteria. |
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babawali@world.com
medicine forum addict
Joined: 29 Apr 2006
Posts: 81
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| Posted: Sat Jun 10, 2006 11:04 am Post subject:
Re: Tuberculosis / iron acquisition
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"in those kids with malaria. We've been killing them by the millions .."
Why would you be infecting children? |
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ironjustice@aol.com
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1522
|
| Posted: Sat Jun 10, 2006 3:20 pm Post subject:
Re: Tuberculosis / iron acquisition
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babawali@world.com wrote:
| Quote: | "in those kids with malaria. We've been killing them by the millions .."
Why would you be infecting children?
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You have something to add .. ?
Do ya .. ?
"I .. am .. stupid .."
I suggest the above would have been more .. apropos ..
Heh .. heh ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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