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Guest
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 Posted: Mon Jun 06, 2005 7:37 pm Post subject:
stopping statin
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i have read that whenever one stops a statin there is a 2-3 week period
in which one experiences increased platelet stickiness. i am unable to
re-access this information to substatiate. in the meantime, what would
one take to decrease platelet stickiness? aspirin? plavix? high dose
vit C???? thanks |
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Susan
medicine forum Guru
Joined: 05 May 2005
Posts: 932
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| Posted: Mon Jun 06, 2005 8:56 pm Post subject:
Re: stopping statin
|
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|
x-no-archive: yes
mmlevy46@hotmail.com wrote:
| Quote: | i have read that whenever one stops a statin there is a 2-3 week period
in which one experiences increased platelet stickiness. i am unable to
re-access this information to substatiate. in the meantime, what would
one take to decrease platelet stickiness? aspirin? plavix? high dose
vit C???? thanks
|
Some things to research: low dose aspirin, fish oil, pycnogenol, garlic,
vitamin E.
Susan |
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Andrew B. Chung, MD/PhD
medicine forum Guru
Joined: 25 Mar 2005
Posts: 8540
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Juhana Harju
medicine forum Guru
Joined: 06 May 2005
Posts: 1056
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| Posted: Tue Jun 07, 2005 5:43 am Post subject:
Re: stopping statin
|
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|
mmlevy46@hotmail.com wrote:
:: i have read that whenever one stops a statin there is a 2-3 week
:: period in which one experiences increased platelet stickiness. i am
:: unable to re-access this information to substatiate. in the
:: meantime, what would one take to decrease platelet stickiness?
:: aspirin? plavix? high dose vit C???? thanks
Fish oil capsules as a supplement and vitamin E.
--
Juhana |
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Jim Chinnis
medicine forum Guru
Joined: 30 Apr 2005
Posts: 1030
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| Posted: Tue Jun 07, 2005 3:00 pm Post subject:
Re: stopping statin
|
|
|
mmlevy46@hotmail.com wrote in part:
| Quote: | i have read that whenever one stops a statin there is a 2-3 week period
in which one experiences increased platelet stickiness. i am unable to
re-access this information to substatiate. in the meantime, what would
one take to decrease platelet stickiness? aspirin? plavix? high dose
vit C???? thanks
|
Statins (at least atorvastatin) reduces the expression of CD36 and
lectin-like oxidized-LDL receptor-1, which is present in
platelets. Based on a couple of studies, it looks like there is a
rebound period of receptor expression and therefore platelet
stickiness after discontinuing a statin that peaks around 14 days.
I would choose low-dose aspirin or plavix, if I were not already
on one. I'd think most people on statins already would be on
low-dose aspirin or plavix, but I may be wrong.
Anything that reduces oxidized LDL might help to reduce risk as
well.
You may be referring to these studies:
Thromb Haemost. 2003 Sep;90(3):476-82. Related Articles, Links
Platelet hyperactivity after statin treatment discontinuation.
Puccetti L, Pasqui AL, Pastorelli M, Bova G, Di Renzo M, Leo A,
Cercignani M, Palazzuoli A, Auteri A, Bruni F.
Department of Clinical Medicine and Immunological Sciences,
Internal Medicine Division, Policlinico Le Scotte, V. le Bracci,
53100, Siena, Italy. puccetti@unisi.it
Hydroxymethyl-glutaryl-CoA-reductase inhibitors (statins) reduce
cardiovascular events by cholesterol lowering as well as by
non-lipid related actions. Among them, the modulation of platelet
activity could play a relevant role in vascular protection.
Furthermore withdrawal of statins has been associated with
increased cardiovascular event rate. The aim of our study was to
evaluate platelet activity after cerivastatin discontinuation in
eighteen subjects that did not accept other drugs and in sixteen
subjects continuing treatment with simvastatin. Fourteen subjects
at the end of the discontinuation period decided to receive other
drugs (simvastatin) and they were evaluted six weeks later. We
measured complete lipid profile by the chromogenic method (LDL-C
was calculated); oxidized-LDL (ox-LDL; ELISA), platelet P-selectin
(P-sel) expression (flow cytometry detection), platelet
aggregation (% change of transmitted light), intracellular
citrullin production (iCit; HPLC) as an indicator of intracellular
NO synthase activity at baseline and 7, 14, 28, 60 days after
statin discontinuation. P-sel expression and platelet aggregation
were increased at 14 days (p < 0.001 and p < 0.05) in association
with raised ox-LDL (r = 0.30, p < 0.05) and decreased iCit (r =
0.53, p < 0.01). Increased LDL-C was related to P-sel and platelet
aggregation at 28 days (r = 0.30, p < 0.05). Subjects continuing
statin treatment had no significant changes of P-sel at 28 (p =
0.221) and 60 days (p = 0.238). Subjects treated with simvastatin
after 60 days of diet showed a significant reduction of P-sel and
platelet aggregation after six weeks of treatment (p < 0.01). Our
data suggest a platelet hyperactivation state in the second week
after statin discontinuation which is partially related to raised
LDL-C. Such a finding could participate in the increased
cardiovascular event rate after statin discontinuation.
Circulation. 2002 Mar 26;105(12):1446-52. Related Articles, Links
Comment in:
Circulation. 2002 Mar 26;105(12):e9085-90.
Circulation. 2003 Jan 28;107(3):e27.
Circulation. 2004 Oct 19;110(16):2280-2.
Withdrawal of statins increases event rates in patients with acute
coronary syndromes.
Heeschen C, Hamm CW, Laufs U, Snapinn S, Bohm M, White HD;
Platelet Receptor Inhibition in Ischemic Syndrome Management
(PRISM) Investigators.
University Hospital Frankfurt, Germany.
BACKGROUND: HMG-CoA Reductase Inhibitors (statins) reduce cardiac
event rates in patients with stable coronary heart disease.
Withdrawal of chronic statin treatment during acute coronary
syndromes may impair vascular function independent of
lipid-lowering effects and thus increase cardiac event rate.
METHODS AND RESULTS: We investigated the effects of statins on the
cardiac event rate in 1616 patients of the Platelet Receptor
Inhibition in Ischemic Syndrome Management (PRISM) study who had
coronary artery disease and chest pain in the previous 24 hours.
We recorded death and nonfatal myocardial infarction during the
30-day follow-up. Baseline clinical characteristics did not differ
among 1249 patients without statin therapy, 379 patients with
continued statin therapy, and 86 patients with discontinued statin
therapy after hospitalization. Statin therapy was associated with
a reduced event rate at 30-day follow-up compared with patients
without statins (adjusted hazard ratio, 0.49 [95% CI, 0.21 to
0.86]; P=0.004). If the statin therapy was withdrawn after
admission, cardiac risk increased compared with patients who
continued to receive statins (2.93 [95% CI, 1.64 to 6.27];
P=0.005) and tended to be higher compared with patients who never
received statins (1.69 [95% CI, 0.92 to 3.56]; P=0.15). This was
related to an increased event rate during the first week after
onset of symptoms and was independent of cholesterol levels. In a
multivariate model, troponin T elevation (P=0.005), ST changes
(P=0.02), and continuation of statin therapy (P=0.008) were the
only independent predictors of patient outcome. CONCLUSIONS:
Statin pretreatment in patients with acute coronary syndromes is
associated with improved clinical outcome. However,
discontinuation of statins after onset of symptoms completely
abrogates this beneficial effect.
--
Jim Chinnis Warrenton, Virginia, USA |
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outrider
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1155
|
| Posted: Tue Jun 07, 2005 3:29 pm Post subject:
Re: stopping statin
|
|
|
Jim I have spent considerable time searching, unsuccessfully, for a
study that refuted this idea one must not stop statins abruptly. It
received little press at the time of release, but it's out there, and
was done by one of the authors of the previous studies. I will continue
to search.
But I have a question: would the platelet stickiness not just return to
what it had been before taking a statin?
I viewed these studies as somewhat alarming, unnecessarily so, and
implying that we had to stay on statins or cause some thrombolytic
catastrophe, which may not be so.
Your clarification would be helpful and much appreciated.
La Statinista |
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William Wagner
medicine forum Guru
Joined: 29 Apr 2005
Posts: 809
|
| Posted: Tue Jun 07, 2005 3:33 pm Post subject:
Re: stopping statin
|
|
|
In article <e4kba156b65dmq1j61nrt070tan2sn1g6g@4ax.com>,
Jim Chinnis <jchinnis@SPAMalum.mit.edu> wrote:
| Quote: |
Anything that reduces oxidized LDL might help to reduce risk as
well.
|
Hi Jim!
Would/could increasing HDL reduce risk?
This seems to be my motive operandi as lowering LDL is hurtful big
time.
What is a poor/ good/great ratio? This from a 39 kind of guy with a 38
intuition.
Bill
--
Garden in shade Zone 5 S Jersey USA
Long -75.0246 Lat 39.637876
"There are no significant bugs in our released software that any significant
number of users want fixed." Bill Gates |
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Robert
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1700
|
| Posted: Tue Jun 07, 2005 3:59 pm Post subject:
Re: stopping statin
|
|
|
"Jim Chinnis" <jchinnis@SPAMalum.mit.edu> wrote in message
news:e4kba156b65dmq1j61nrt070tan2sn1g6g@4ax.com...
| Quote: | mmlevy46@hotmail.com wrote in part:
i have read that whenever one stops a statin there is a 2-3 week period
in which one experiences increased platelet stickiness. i am unable to
re-access this information to substatiate. in the meantime, what would
one take to decrease platelet stickiness? aspirin? plavix? high dose
vit C???? thanks
Statins (at least atorvastatin) reduces the expression of CD36 and
lectin-like oxidized-LDL receptor-1, which is present in
platelets. Based on a couple of studies, it looks like there is a
rebound period of receptor expression and therefore platelet
stickiness after discontinuing a statin that peaks around 14 days.
I would choose low-dose aspirin or plavix, if I were not already
on one. I'd think most people on statins already would be on
low-dose aspirin or plavix, but I may be wrong.
Anything that reduces oxidized LDL might help to reduce risk as
well.
You may be referring to these studies:
Thromb Haemost. 2003 Sep;90(3):476-82. Related Articles, Links
Platelet hyperactivity after statin treatment discontinuation.
Puccetti L, Pasqui AL, Pastorelli M, Bova G, Di Renzo M, Leo A,
Cercignani M, Palazzuoli A, Auteri A, Bruni F.
Department of Clinical Medicine and Immunological Sciences,
Internal Medicine Division, Policlinico Le Scotte, V. le Bracci,
53100, Siena, Italy. puccetti@unisi.it
Hydroxymethyl-glutaryl-CoA-reductase inhibitors (statins) reduce
cardiovascular events by cholesterol lowering as well as by
non-lipid related actions. Among them, the modulation of platelet
activity could play a relevant role in vascular protection.
Furthermore withdrawal of statins has been associated with
increased cardiovascular event rate. The aim of our study was to
evaluate platelet activity after cerivastatin discontinuation in
eighteen subjects that did not accept other drugs and in sixteen
subjects continuing treatment with simvastatin. Fourteen subjects
at the end of the discontinuation period decided to receive other
drugs (simvastatin) and they were evaluted six weeks later. We
measured complete lipid profile by the chromogenic method (LDL-C
was calculated); oxidized-LDL (ox-LDL; ELISA), platelet P-selectin
(P-sel) expression (flow cytometry detection), platelet
aggregation (% change of transmitted light), intracellular
citrullin production (iCit; HPLC) as an indicator of intracellular
NO synthase activity at baseline and 7, 14, 28, 60 days after
statin discontinuation. P-sel expression and platelet aggregation
were increased at 14 days (p < 0.001 and p < 0.05) in association
with raised ox-LDL (r = 0.30, p < 0.05) and decreased iCit (r =
0.53, p < 0.01). Increased LDL-C was related to P-sel and platelet
aggregation at 28 days (r = 0.30, p < 0.05). Subjects continuing
statin treatment had no significant changes of P-sel at 28 (p =
0.221) and 60 days (p = 0.238). Subjects treated with simvastatin
after 60 days of diet showed a significant reduction of P-sel and
platelet aggregation after six weeks of treatment (p < 0.01). Our
data suggest a platelet hyperactivation state in the second week
after statin discontinuation which is partially related to raised
LDL-C. Such a finding could participate in the increased
cardiovascular event rate after statin discontinuation.
Circulation. 2002 Mar 26;105(12):1446-52. Related Articles, Links
Comment in:
Circulation. 2002 Mar 26;105(12):e9085-90.
Circulation. 2003 Jan 28;107(3):e27.
Circulation. 2004 Oct 19;110(16):2280-2.
Withdrawal of statins increases event rates in patients with acute
coronary syndromes.
Heeschen C, Hamm CW, Laufs U, Snapinn S, Bohm M, White HD;
Platelet Receptor Inhibition in Ischemic Syndrome Management
(PRISM) Investigators.
University Hospital Frankfurt, Germany.
BACKGROUND: HMG-CoA Reductase Inhibitors (statins) reduce cardiac
event rates in patients with stable coronary heart disease.
Withdrawal of chronic statin treatment during acute coronary
syndromes may impair vascular function independent of
lipid-lowering effects and thus increase cardiac event rate.
METHODS AND RESULTS: We investigated the effects of statins on the
cardiac event rate in 1616 patients of the Platelet Receptor
Inhibition in Ischemic Syndrome Management (PRISM) study who had
coronary artery disease and chest pain in the previous 24 hours.
We recorded death and nonfatal myocardial infarction during the
30-day follow-up. Baseline clinical characteristics did not differ
among 1249 patients without statin therapy, 379 patients with
continued statin therapy, and 86 patients with discontinued statin
therapy after hospitalization. Statin therapy was associated with
a reduced event rate at 30-day follow-up compared with patients
without statins (adjusted hazard ratio, 0.49 [95% CI, 0.21 to
0.86]; P=0.004). If the statin therapy was withdrawn after
admission, cardiac risk increased compared with patients who
continued to receive statins (2.93 [95% CI, 1.64 to 6.27];
P=0.005) and tended to be higher compared with patients who never
received statins (1.69 [95% CI, 0.92 to 3.56]; P=0.15). This was
related to an increased event rate during the first week after
onset of symptoms and was independent of cholesterol levels. In a
multivariate model, troponin T elevation (P=0.005), ST changes
(P=0.02), and continuation of statin therapy (P=0.008) were the
only independent predictors of patient outcome. CONCLUSIONS:
Statin pretreatment in patients with acute coronary syndromes is
associated with improved clinical outcome. However,
discontinuation of statins after onset of symptoms completely
abrogates this beneficial effect.
--
Jim Chinnis Warrenton, Virginia, USA
|
Good post. That is consistent with my understandings.
There is the so called "sticky platelet syndrome" that is picked up with
platelet aggregation studies.
Again you look at the numbers and people over react without looking at the
numbers. So you have people panicking with rhabdo and you have people
panicking with sticky platelets in stopping of statins. No need to panic in
either case. |
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Jim Chinnis
medicine forum Guru
Joined: 30 Apr 2005
Posts: 1030
|
| Posted: Tue Jun 07, 2005 5:06 pm Post subject:
Re: stopping statin
|
|
|
"zee" <outrider@despammed.com> wrote in part:
| Quote: | Jim I have spent considerable time searching, unsuccessfully, for a
study that refuted this idea one must not stop statins abruptly. It
received little press at the time of release, but it's out there, and
was done by one of the authors of the previous studies. I will continue
to search.
But I have a question: would the platelet stickiness not just return to
what it had been before taking a statin?
I viewed these studies as somewhat alarming, unnecessarily so, and
implying that we had to stay on statins or cause some thrombolytic
catastrophe, which may not be so.
Your clarification would be helpful and much appreciated.
La Statinista
|
I think the first paper I cited is more informative than the
second, despite being a laboratory study. In the second paper, it
says,
"If the statin therapy was withdrawn after
admission, cardiac risk ... tended to be higher compared with
patients who never received statins (1.69 [95% CI, 0.92 to 3.56];
P=0.15). This was related to an increased event rate during the
first week after onset of symptoms and was independent of
cholesterol levels."
This is a non-significant result. Even if it were significant, it
would be hard to interpret. Note also that it applies to patients
with *acute* coronary syndrome.
The first study addresses the question posed by the OP. It does
show an increase in platelet stickiness at around 14 days
post-statin discontinuance. And it shows a mechanism.
A moderate increase in platelet stickiness for a few days or so in
an asymptomatic patient may not be huge deal. I don't think we
know, really. The second study showed no statistically significant
effect even in those patients hospitalized for heart disease
problems.
Taken as a whole, I wouldn't be terribly concerned. But returning
to the OP's question, I'd probably go on or stay on my
aspirin/plavix if possible for a few weeks. And I might up or
maintain my intake of vitamins C, E, and carotenoids, cocoa, tea,
etc.
--
Jim Chinnis Warrenton, Virginia, USA |
|
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|
|
Jim Chinnis
medicine forum Guru
Joined: 30 Apr 2005
Posts: 1030
|
| Posted: Tue Jun 07, 2005 5:16 pm Post subject:
Re: stopping statin
|
|
|
William Wagner <b2wagner@snip.net> wrote in part:
| Quote: | In article <e4kba156b65dmq1j61nrt070tan2sn1g6g@4ax.com>,
Jim Chinnis <jchinnis@SPAMalum.mit.edu> wrote:
Anything that reduces oxidized LDL might help to reduce risk as
well.
Hi Jim!
Would/could increasing HDL reduce risk?
|
I don't think it would blunt any temporary increase in platelet
stickiness, no.
| Quote: | This seems to be my motive operandi as lowering LDL is hurtful big
time.
|
If you aren't taking a statin, this issue doesn't apply to you.
| Quote: | What is a poor/ good/great ratio? This from a 39 kind of guy with a 38
intuition.
|
I think that's a big topic, and one I'm not an expert on. I also
think target ratios should reflect your own personal risk factors.
If you have bad particle sizes, high homocysteine, high Lp(a),
high hsCRP, high blood glucose, etc., you may need better ratios
than someone who lacks those additional risk factors.
Higher HDL is certainly a good thing.
--
Jim Chinnis Warrenton, Virginia, USA |
|
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|
|
Guest
|
| Posted: Tue Jun 07, 2005 5:38 pm Post subject:
Re: stopping statin
|
|
|
thanks for all the answers--and jim chinnis, thank you for the
references and explanations of same! |
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outrider
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1155
|
| Posted: Tue Jun 07, 2005 5:50 pm Post subject:
Re: stopping statin
|
|
|
mmlevy46@hotmail.com wrote:
| Quote: | thanks for all the answers--and jim chinnis, thank you for the
references and explanations of same!
|
Jim Chinnis is our resident smart guy (and rounds that out with a lot
of 'nice guy' too). We're so lucky to have him here.
Zee |
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Robert
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1700
|
| Posted: Tue Jun 07, 2005 6:20 pm Post subject:
Re: stopping statin
|
|
|
"Jim Chinnis" <jchinnis@SPAMalum.mit.edu> wrote in message
news:pcrba1tdipr7vtvs387sc2rpvkt08f0jql@4ax.com...
| Quote: | "zee" <outrider@despammed.com> wrote in part:
Jim I have spent considerable time searching, unsuccessfully, for a
study that refuted this idea one must not stop statins abruptly. It
received little press at the time of release, but it's out there, and
was done by one of the authors of the previous studies. I will continue
to search.
But I have a question: would the platelet stickiness not just return to
what it had been before taking a statin?
I viewed these studies as somewhat alarming, unnecessarily so, and
implying that we had to stay on statins or cause some thrombolytic
catastrophe, which may not be so.
Your clarification would be helpful and much appreciated.
La Statinista
I think the first paper I cited is more informative than the
second, despite being a laboratory study. In the second paper, it
says,
"If the statin therapy was withdrawn after
admission, cardiac risk ... tended to be higher compared with
patients who never received statins (1.69 [95% CI, 0.92 to 3.56];
P=0.15). This was related to an increased event rate during the
first week after onset of symptoms and was independent of
cholesterol levels."
This is a non-significant result. Even if it were significant, it
would be hard to interpret. Note also that it applies to patients
with *acute* coronary syndrome.
The first study addresses the question posed by the OP. It does
show an increase in platelet stickiness at around 14 days
post-statin discontinuance. And it shows a mechanism.
A moderate increase in platelet stickiness for a few days or so in
an asymptomatic patient may not be huge deal. I don't think we
know, really. The second study showed no statistically significant
effect even in those patients hospitalized for heart disease
problems.
Taken as a whole, I wouldn't be terribly concerned. But returning
to the OP's question, I'd probably go on or stay on my
aspirin/plavix if possible for a few weeks. And I might up or
maintain my intake of vitamins C, E, and carotenoids, cocoa, tea,
etc.
--
Jim Chinnis Warrenton, Virginia, USA
|
I forgot to add that we are involved with a clinical trials looking into
aspirin and plavix resistance. Patients who have been taking aspirin to
prevent heart attacks can be doing so with no benefit because of their
resistance. This can be tested in vitro on whether the platelets are
inhibited or not. We ask if they have been taking either drug and then do
testing for that resistance for each drug.
The moral of the story is that the aspirin you have been taking to prevent
arterial thrombosis may not be doing nothing at all.
Venous thrombosis are caused by blood coagulation factor activation and thus
heparin therapy.
DVT is not related to arterial thrombosis usually. |
|
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|
|
Robert
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1700
|
| Posted: Tue Jun 07, 2005 6:27 pm Post subject:
Re: stopping statin
|
|
|
"Jim Chinnis" <jchinnis@SPAMalum.mit.edu> wrote in message
news:n5sba1hoj7psd20dnjoefv32qdrsa44kel@4ax.com...
| Quote: | William Wagner <b2wagner@snip.net> wrote in part:
In article <e4kba156b65dmq1j61nrt070tan2sn1g6g@4ax.com>,
Jim Chinnis <jchinnis@SPAMalum.mit.edu> wrote:
Anything that reduces oxidized LDL might help to reduce risk as
well.
Hi Jim!
Would/could increasing HDL reduce risk?
I don't think it would blunt any temporary increase in platelet
stickiness, no.
This seems to be my motive operandi as lowering LDL is hurtful big
time.
If you aren't taking a statin, this issue doesn't apply to you.
What is a poor/ good/great ratio? This from a 39 kind of guy with a 38
intuition.
I think that's a big topic, and one I'm not an expert on. I also
think target ratios should reflect your own personal risk factors.
If you have bad particle sizes, high homocysteine, high Lp(a),
high hsCRP, high blood glucose, etc., you may need better ratios
than someone who lacks those additional risk factors.
|
The VAP panel tests for all those things compared to the regular lipid
panel.
Each and every independent risk factor is independent and simply looking "a"
number rather than "numbers" is the wrong way to go.
The normal lipid panel does not look at particle size and thus the value may
be normal but of abnormal quality size and thus at high risk. These are the
patients with so called normal lipid panels and then die of a heart attack.
The goal is to find EVERY risk factor and not just look at one big one like
LDL/HDL ratio.
| Quote: |
Higher HDL is certainly a good thing.
--
Jim Chinnis Warrenton, Virginia, USA |
|
|
| Back to top |
|
|
Jason
medicine forum Guru
Joined: 29 Apr 2005
Posts: 1120
|
| Posted: Tue Jun 07, 2005 6:54 pm Post subject:
Re: stopping statin
|
|
|
In article <pcrba1tdipr7vtvs387sc2rpvkt08f0jql@4ax.com>, Jim Chinnis
<jchinnis@SPAMalum.mit.edu> wrote:
| Quote: | "zee" <outrider@despammed.com> wrote in part:
Jim I have spent considerable time searching, unsuccessfully, for a
study that refuted this idea one must not stop statins abruptly. It
received little press at the time of release, but it's out there, and
was done by one of the authors of the previous studies. I will continue
to search.
But I have a question: would the platelet stickiness not just return to
what it had been before taking a statin?
I viewed these studies as somewhat alarming, unnecessarily so, and
implying that we had to stay on statins or cause some thrombolytic
catastrophe, which may not be so.
Your clarification would be helpful and much appreciated.
La Statinista
I think the first paper I cited is more informative than the
second, despite being a laboratory study. In the second paper, it
says,
"If the statin therapy was withdrawn after
admission, cardiac risk ... tended to be higher compared with
patients who never received statins (1.69 [95% CI, 0.92 to 3.56];
P=0.15). This was related to an increased event rate during the
first week after onset of symptoms and was independent of
cholesterol levels."
This is a non-significant result. Even if it were significant, it
would be hard to interpret. Note also that it applies to patients
with *acute* coronary syndrome.
The first study addresses the question posed by the OP. It does
show an increase in platelet stickiness at around 14 days
post-statin discontinuance. And it shows a mechanism.
A moderate increase in platelet stickiness for a few days or so in
an asymptomatic patient may not be huge deal. I don't think we
know, really. The second study showed no statistically significant
effect even in those patients hospitalized for heart disease
problems.
Taken as a whole, I wouldn't be terribly concerned. But returning
to the OP's question, I'd probably go on or stay on my
aspirin/plavix if possible for a few weeks. And I might up or
maintain my intake of vitamins C, E, and carotenoids, cocoa, tea,
etc.
--
Jim Chinnis Warrenton, Virginia, USA
|
Hello,
I read the various posts related to "stopping statins". I just wanted
everyone to know that my research has showed that the vast majority of
people that take statins do NOT develop any bad side effects. I hope that
as a result of my various posts that those lucky people don't stop taking
statins. However, for those people that do develop serious side effects
such as muscle pains, tendinopathy, myopathy and other problems--my advice
is to call your doctor ASAP . In my case, I stopped taking statins and red
yeast rice capsules until I see my doctor in about one month.
Jason
--
NEWSGROUP SUBSCRIBERS MOTTO
We respect those subscribers that ask for advice or provide advice.
We do NOT respect the subscribers that enjoy criticizing people. |
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