Severe oxidative stress / HIV / AIDS

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

: Afr J Med Med Sci. 2005 Sep;34(3):221-5. Links

Total antioxidant status and lipid peroxidation in HIV-1 infected
patients in a rural area of south western Nigeria.

Ogunro PS, Ogungbamigbe TO, Ajala MO, Egbewale BE.

Department of Chemical Pathology, College of Health Sciences, Ladoke
Akintola University of Technology, Osogbo, Nigeria. ogunrops@yahoo.com

Total serum antioxidant status (TAS) and lipid peroxidation were
evaluated in 62 HIV-1 seropositive patients before the commencement of
antiretroviral drug therapy. Twenty-four (24) age-marched and
apparently healthy HIV-1 seronegative subjects were recruited as
control subjects. HIV-1 seropositive patients were classified according
to the Centre for Disease Control and Prevention (CDC) Criteria. The
mean serum malondialdehyde (MDA) concentrations of 5.58 +/- 0.99nmol/ml
and 4.24 +/- 0.80nmol/ml were significantly elevated in HIV-1 infected
patients with CD4+ count of <200 lym/mm3 and that of 200-499 lym/mm3
respectively when compared with the control which is 3.37 +/- 0.56nmol/
ml (P<0.001). Whereas when compared with control, the serum MDA
concentration of 3.45 +/- 0.48nmol/ml in HIV-1 patients with CD4+ count
of >500 lym/mm3 was not significant (P>0.05). In the intra groups
comparison serum concentration of MDA were significantly elevated when
compared with each other (P<0.001). The mean serum total antioxidant
status (TAS) of 1.30 +/- 0.11mmol/L, 1.12 +/- 0.24 mmol/L and 0.95 +/-
0.17mmol/L of HIV- 1 seropositive patients with CD4+ count of >500
lym/mm3, 200-499 lym/mm3 and <200 lym/mm3 respectively were
significantly reduced compared with 1.69 +/- 0.23mmol/L for the control
group (P<0.001). Similarly in the intra groups comparison, serum
concentration of TAS were significantly reduced when compared with each
other (P<0.001). The weight of 54.81 +/- 5.13 Kg for HIV-I seropositive
patients with CD4+ count of <200 lym/mm3 was significantly reduced when
compared with 69.17 +/- 4.38Kg for the control (P<0.05). Our results
clearly show that severe oxidative stress occurs in the serum of
seropositive patients in comparison with controls, and increases
significantly with the progression of disease, i.e. AIDS > symptomatics

babawali@world.com · medicine forum addict Joined: 29 Apr 2006 Posts: 81

Ah, the evil oxygen rears its ugly head again, oxygen is the cause of all
disease.

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