Iron metabolism in the development of diabetes

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Rev Clin Esp. 2006 Apr;206(4):167-71. Links

[Hepatitis C as a risk factor of diabetes mellitus type 2.]

[Article in Spanish]

Virseda Chamorro I, Virseda Chamorro M, Prieto Carbajo RI, Jaqueti
Aroca J.

Servicio de Analisis Clinicos y Servicio de Microbiologia. Hospital
Central de la Defensa Gomez Ulla. Madrid. Espana.

INTRODUCTION. Hepatitis C virus (HCV) has been implicated as a risk
factor for the development of diabetes mellitus, type 2 (DM2). Our aim
is to check if HCV infection in our patients is a risk for the
development of DM2. In that case, we study if the possible pathogenic
mechanism could be related with an increase in iron deposits. PATIENTS
AND METHOD. A consecutive series of 305 patients that attended to our
service for measurement of anti-HCV antibodies was collected.
HCV-antibodies were identified by second generation ELISA and confirmed
by immunoblot. We detected viral RNA in 56% of these patients by
polymerase chain reaction. The control group was made up of 137
patients. In every case, we analyzed the plasma levels of glucose,
ferritin and other biochemical parameters. RESULTS. We found 13% of
diabetics in the patient with viral RNA, 9.3% in the infected patients
without RNA and 3.9% in the controls. The average of the ferritin level
for the infected patients was 256 mg/l and for the controls was 151
mg/l (p = 0.01). The diabetic patients had ferritin levels of 346 mg/l
and non-diabetic patients had 218 mg/l (p = 0.038). The presenceof
HCV-antibodies showed a 2.78 odds ratio for diabetes risk. DISCUSSION.
Our results showed a relationship between HCV infection and diabetes
mellitus type 2, so that the percentage of diabetics increased
parallelly with the degree of viral activity and the variable
<<presence of HCV-antibodies>> was the one that most contributed to the
risk. Although our results would support the role of the iron
metabolism in the development of diabetes, follow-up studies of a
cohort of patients infected by HCV would be necessary to contrast this
statement.

PMID: 16750086 [PubMed - in process]

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