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Forum index » Medicine forums » nutrition
Iron-catalysed degenerative joint damage
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ironjustice@aol.com
medicine forum Guru


Joined: 28 Apr 2005
Posts: 1522

PostPosted: Fri Jun 02, 2006 10:17 am    Post subject: Iron-catalysed degenerative joint damage Reply with quote
<<snip>>
iron-catalysed formation of destructive oxygen metabolites
<<snip>>

Haemophilia. 2006 Jul;12 Suppl 3:117-21. Related Articles, Links


Pathogenesis of haemophilic arthropathy.

Roosendaal G, Lafeber FP.

University Medical Center Utrecht, Utrecht, The Netherlands.

Summary. The pathogenetic mechanism of haemophilic arthropathy is
multifactorial and includes degenerative cartilage-mediated and
inflammatory synovium-mediated components. Intra-articular blood first
has a direct effect on cartilage, as a result of the iron-catalysed
formation of destructive oxygen metabolites (resulting in chondrocyte
apoptosis), and subsequently affects the synovium, in addition to
haemosiderin-induced synovial triggering. Both processes occur in
parallel, and while they influence each other they probably do not
depend on each other. This concept resembles degenerative joint damage
as found in osteoarthritis as well as inflammatory processes in
rheumatoid arthritis. These processes finally result in a fibrotic and
destroyed joint.

PMID: 16684006 [PubMed - in process]

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babawali@world.com
medicine forum addict


Joined: 29 Apr 2006
Posts: 81

PostPosted: Fri Jun 02, 2006 11:53 am    Post subject: Re: Iron-catalysed degenerative joint damage Reply with quote
"Pathogenesis of haemophilic arthropathy."

A genetic disorder not relevant to the population at large.
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Norman
medicine forum beginner


Joined: 22 Sep 2005
Posts: 8

PostPosted: Sat Jun 03, 2006 2:43 am    Post subject: Re: Iron-catalysed degenerative joint damage Reply with quote
Quote:
A genetic disorder not relevant to the population at large.

Neither is Tommy boy...
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