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ironjustice@aol.com
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1522
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 Posted: Tue May 30, 2006 2:51 pm Post subject:
Is hypertension an inflammatory process?
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Is hypertension an inflammatory process?
Boos CJ, Lip GY
Curr Pharm Des. 2006; 12(13): 1623-35
The risk factors for hypertension are only partly known, and accounts
for the some of the deficiencies in current primary prevention
strategies and in the design of new drugs for the management of this
common condition. Recently, chronic low grade low-grade inflammation
has been identified as an integral part in the pathogenesis of vascular
disease. Of note, inflammation may also be implicated in the
development of hypertension, either as a primary or secondary event.
Indeed, several clinical studies have demonstrated increased numbers of
well recognised pro-inflammatory markers, such as high sensitive
C-reactive protein (hsCRP), in patients with hypertension, even after
adjustment for potential confounding factors. Furthermore, elevated
hsCRP levels have also been shown to be predictive for the development
of hypertension in prehypertensive and normotensive patients.
Pathophysiologically, inflammation has been implicated in both
endothelial (dys)function and arterial stiffness in hypertension, with
reduced availability of nitric oxide (NO) being integral to this
process. Oxidative stress also appears to be a key feature in the
reduced availability of NO and is aggravated by increased circulating
angiotensin II (Ang II). Importantly, there is some evidence that drugs
commonly used in the management of hypertension, such as statins,
angiotensin converting enzyme inhibitors and Ang II receptor blockers
have anti-inflammatory properties that can positively influence
outcomes in patients with hypertension. The inflammatory state in
hypertension may pose a new therapeutic target for future drug design.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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Kumar
medicine forum Guru
Joined: 10 May 2005
Posts: 870
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| Posted: Wed May 31, 2006 6:25 am Post subject:
Re: Is hypertension an inflammatory process?
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ironjustice@aol.com wrote:
| Quote: | Is hypertension an inflammatory process?
Boos CJ, Lip GY
Curr Pharm Des. 2006; 12(13): 1623-35
The risk factors for hypertension are only partly known, and accounts
for the some of the deficiencies in current primary prevention
strategies and in the design of new drugs for the management of this
common condition. Recently, chronic low grade low-grade inflammation
has been identified as an integral part in the pathogenesis of vascular
disease. Of note, inflammation may also be implicated in the
development of hypertension, either as a primary or secondary event.
Indeed, several clinical studies have demonstrated increased numbers of
well recognised pro-inflammatory markers, such as high sensitive
C-reactive protein (hsCRP), in patients with hypertension, even after
adjustment for potential confounding factors. Furthermore, elevated
hsCRP levels have also been shown to be predictive for the development
of hypertension in prehypertensive and normotensive patients.
Pathophysiologically, inflammation has been implicated in both
endothelial (dys)function and arterial stiffness in hypertension, with
reduced availability of nitric oxide (NO) being integral to this
process. Oxidative stress also appears to be a key feature in the
reduced availability of NO and is aggravated by increased circulating
angiotensin II (Ang II). Importantly, there is some evidence that drugs
commonly used in the management of hypertension, such as statins,
angiotensin converting enzyme inhibitors and Ang II receptor blockers
have anti-inflammatory properties that can positively influence
outcomes in patients with hypertension. The inflammatory state in
hypertension may pose a new therapeutic target for future drug design.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
"Local blood flow control can be divided into two phases; |
1) Acute - rapid change constriction/dilatation of arteriols,
metarteriol et spincters.
2) Long-term control provides a better control by increasing/decreasing
the physical size and number of blood vessels supplying the tissues. "
It may be useful to understand above.
But, inflammation may encourage more fluid filteration by dialation
wheras some hypotencive medicines also act be dilation? |
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Kumar
medicine forum Guru
Joined: 10 May 2005
Posts: 870
|
| Posted: Wed May 31, 2006 8:22 am Post subject:
Re: Is hypertension an inflammatory process?
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Kumar wrote:
| Quote: | ironjustice@aol.com wrote:
Is hypertension an inflammatory process?
Boos CJ, Lip GY
Curr Pharm Des. 2006; 12(13): 1623-35
The risk factors for hypertension are only partly known, and accounts
for the some of the deficiencies in current primary prevention
strategies and in the design of new drugs for the management of this
common condition. Recently, chronic low grade low-grade inflammation
has been identified as an integral part in the pathogenesis of vascular
disease. Of note, inflammation may also be implicated in the
development of hypertension, either as a primary or secondary event.
Indeed, several clinical studies have demonstrated increased numbers of
well recognised pro-inflammatory markers, such as high sensitive
C-reactive protein (hsCRP), in patients with hypertension, even after
adjustment for potential confounding factors. Furthermore, elevated
hsCRP levels have also been shown to be predictive for the development
of hypertension in prehypertensive and normotensive patients.
Pathophysiologically, inflammation has been implicated in both
endothelial (dys)function and arterial stiffness in hypertension, with
reduced availability of nitric oxide (NO) being integral to this
process. Oxidative stress also appears to be a key feature in the
reduced availability of NO and is aggravated by increased circulating
angiotensin II (Ang II). Importantly, there is some evidence that drugs
commonly used in the management of hypertension, such as statins,
angiotensin converting enzyme inhibitors and Ang II receptor blockers
have anti-inflammatory properties that can positively influence
outcomes in patients with hypertension. The inflammatory state in
hypertension may pose a new therapeutic target for future drug design.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
"Local blood flow control can be divided into two phases;
1) Acute - rapid change constriction/dilatation of arteriols,
metarteriol et spincters.
2) Long-term control provides a better control by increasing/decreasing
the physical size and number of blood vessels supplying the tissues. "
It may be useful to understand above.
But, inflammation may encourage more fluid filteration by dialation
wheras some hypotencive medicines also act be dilation?
|
Furthur, theee may be some opposition of blood flow and pressure in
upstream and downstream vessels due to local blood flow controls which
may cause some confusions in understanding. |
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ironjustice@aol.com
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1522
|
| Posted: Thu Jun 01, 2006 6:16 am Post subject:
Re: Is hypertension an inflammatory process?
|
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| Quote: | Kumar wrote:
"Local blood flow control can be divided into two phases;
1) Acute - rapid change constriction/dilatation of arteriols,
metarteriol et spincters.
2) Long-term control provides a better control by increasing/decreasing
the physical size and number of blood vessels supplying the tissues. "
It may be useful to understand above.
But, inflammation may encourage more fluid filteration by dialation
wheras some hypotencive medicines also act be dilation?
Furthur, theee may be some opposition of blood flow and pressure in
upstream and downstream vessels due to local blood flow controls which
may cause some confusions in understanding
|
Actually Kumar .. it is the increased blood cells which cause the ..
chronic ... low grade inflammation ..
Vegetarians switching to a meat eating diet have their hematcrits go up
and when switching back have it go .. down.. again.
Meat eaters switching to a vegetarian diet have their hematocrits go
down and when switching back have it go .. up.
PROVING .. since BOTH .. groups .. were healthy men .. THAT ..
'availability' .. accessibility .. OF .. iron .. the HIGHLY absorbable
form of iron from meat .. exclusively .. meat .. CAUSES .. an ..
ABNORMAL .. increase .. in red blood cell production WHICH ..
coincidentally is accompanied by INCREASED c-reactive protein.
Sooooo .. one could theorize the 'slight' increase in hematocrit ..
which 'they' seem to think is "no big deal" .. is actually .. after ALL
... a .. big .. deal.
Chronic low grade inflammation caused by increased viscosity of the
blood .. due to increased red blood cell count.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
.. |
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