Picolinic acid / Targeting the brain

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Drug targeting to the brain: transfer of picolinic acid along the
olfactory pathways.
Bergström U, Franzén A, Eriksson C, Lindh C, Brittebo EB
J Drug Target. 2002 Sep ; 10(6): 469-78

Picolinic acid (PA) protects against quinolinic acid- and kainic
acid-induced neurotoxicity in the brain. To study the uptake of PA to
the brain, we administered [3H]PA via a unilateral nasal instillation
or iv injection to mice. Autoradiography demonstrated a rapid uptake of
radioactivity in the olfactory nerve layer and in the ipsilateral
olfactory bulb (OB) following nasal instillation of [3H]PA. After 4 h,
there was a high level of radioactivity in the central parts of the
ipsilateral OB and olfactory peduncle. Moreover, iv injection of [3H]PA
demonstrated a selective uptake and retention of radioactivity in the
OB. Gas chromatography-mass spectrometry (GC-MS) demonstrated the
presence of PA and PA-glycine conjugate in the OB. In mice with reduced
peripheral olfactory innervations there was a decreased uptake of
[3H]PA in the OB as compared to controls suggesting that an intact
olfactory neuroepithelium is a prerequisite for an uptake of PA to the
OB. There is an increased interest in brain targeting of drugs with
limited ability to pass the blood-brain barrier. The present results
demonstrate that PA fulfils structural requirements for a transfer
along the olfactory pathways to the brain.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Google