Iron chelators in cancer

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Sounds alot like .. picolinic acid .. seeing that it is compared TO ..
potent .. iron chelators AND suggests.." that the major contributor to
the activity is the ligand's ability to form a stable and tight
complex" ..

N-picolyl derivatives of Kemp's triamine as potential antitumor agents:
a preliminary investigation.
Regino CA, Torti SV, Ma R, Yap GP, Kreisel KA, Torti FM, Planalp RP,
Brechbiel MW
J Med Chem. 2005 Dec 15; 48(25): 7993-9

Preorganized tripodal ligands such as the N-picolyl derivatives of
cis,cis-1,3,5-triamino-cis,cis-1,3,5-trimethylcyclohexane (Kemp's
triamine) were prepared as analogues to
N,N',N''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane
(tachpyr) in hopes of enhancing the rate of formation and stability of
the metal complexes. A tricyclic bisaminal was formed via the reduction
of the Schiff base, while the tri(picolyl) derivative was synthesized
via reductive amination of pyridine carboxaldehyde. Their
cytotoxicities to the HeLa cell line were evaluated and directly
compared to tachpyr and
N,N',N''-tris(2-pyridylmethyl)tris(2-aminoethyl)amine (trenpyr).
Results indicate that
N,N',N''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triamino-cis,cis-1,3,5-trimethylcyclohexane
(Kemp's pyr) exhibits cytotoxic activity against the HeLa cancer cell
line comparable to tachpyr (IC50 approximately 8.0 microM). Both Kemp's
pyr and tachpyr show higher cytotoxic activity over the aliphatic
analogue of trenpyr (IC50 approximately 14 microM), suggesting that the
major contributor to the activity is the ligand's ability to form a
stable and tight complex and that the equatorial/axial equilibrium
impacting the complex formation for the cyclohexane-based ligands is
not significant.

<<snip>>
evaluated and directly compared to tachpyr
<<snip>>

http://tinyurl.com/mwvv2

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

babawali.com@nirgendwo · medicine forum beginner Joined: 01 May 2006 Posts: 3

Shows all the earmarks of a crude amateur way over his head because a term
has some similarity to another one. But when this rank amateur states:

"I am now having more success in the medical field THAN ANYONE IN HISTORY"

we must be sure to take notice, just what is left up to the reader. Take
home message for new readers, this form of crude amateur needs to be
exposed so that no one can be harmed.

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Picolinic acid ..

http://tinyurl.com/hfd8y

<<snip>>
The preparations have antineoplastic, antiviral, antiinflammatory,
analgesic antiangiogenic and antiproliferative effects and are used in
the treatment of warts, psoriasis, acne, cancers, sunburn, inflammatory
responses, untoward angiogenesis and other diseases and in the
prevention of sexually transmitted diseases such as genital warts,
herpes and AIDS.
<<snip>>

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

babawali@world.com · medicine forum addict Joined: 29 Apr 2006 Posts: 81

"Type in picolinic acid .. and you GET .. that .. specific .. article .."

This is what comes when a crude amateur does not know what he is reading
because the material is far above his commprehention level and experience.
In medline there is a word list it consults when trying tofind related
topics and you get these results. Why do you assume that picolinic acid
is the same in its biological activity as some form of picolyl?

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

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