Wrong Vit E can KILL YOU!!!! Correct ones really help.

Jack N Dalton · medicine forum beginner Joined: 22 Jun 2005 Posts: 7

Just the results of my research with a little opinion added.

jack n dalton

1: J Nutr. 2003 Oct;133(10):3137-40.
Supplementation of diets with alpha-tocopherol reduces serum concentrations
of gamma- and delta-tocopherol in humans.

Huang HY, Appel LJ.

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins
University, Baltimore, MD 21205, USA.

Despite promising evidence from in vitro experiments and observational
studies, supplementation of diets with alpha-tocopherol has not reduced the
risk of cardiovascular disease and cancer in most large-scale clinical
trials. One plausible explanation is that the potential health benefits of
alpha-tocopherol supplements are offset by deleterious changes in the
bioavailability and/or bioactivity of other nutrients. We studied the
effects of supplementing diets with RRR-alpha-tocopheryl acetate (400 IU/d)
on serum concentrations of gamma- and delta-tocopherol in a randomized,
placebo-controlled trial in 184 adult nonsmokers. Outcomes were changes in
serum concentrations of gamma- and delta-tocopherol from baseline to the end
of the 2-mo experimental period. Compared with placebo, supplementation with
alpha-tocopherol reduced serum gamma-tocopherol concentrations by a median
change of 58% [95% CI = (51%, 66%), P < 0.0001], and reduced the number of
individuals with detectable delta-tocopherol concentrations (P < 0.0001).
Consistent with trial results were the results from baseline cross-sectional
analyses, in which prior vitamin E supplement users had significantly lower
serum gamma-tocopherol than nonusers. In view of the potential benefits of
gamma- and delta-tocopherol, the efficacy of alpha-tocopherol
supplementation may be reduced due to decreases in serum gamma- and
delta-tocopherol levels. Additional research is clearly warranted.

Publication Types:
* Clinical Trial
* Randomized Controlled Trial

PMID: 14519797 [PubMed - indexed for MEDLINE]
..
..

1. Gamma E is protective of the hart and cardiovascular system.

2. Taking alpha-tocopherol displaces the GOOD vit E ie the Gamma E

3. Rate of DEATH and heart disease GOES UP with increased amount of Vit E
alpha-tocopherol supplementation.

4. This is because IT (alpha-tocopherol vit e) DISPLACES THE GOOD GAMMA E.

5. Tocotrienols: GO WAY BEYOND TOCOPHEROLS. Tocotrienols are
neuroprotective. Do a search of pubmed "Tocotrienols neurons".
(Tocotrienols are somewhat expensive)

http://www.pubmed.gov

6. The body uses large amounts of alpha-tocopherol vit e. Getting about 400
mg in a multivitamin is a good idea.

7. However it is best NOT to take extra alpha-tocopherol vit e beyond that.

8. It is much healthier to take extra Gamma E Tocopherol/Tocotrienols Vit E.
Taking extra alpha-tocopherol vit E increases mortality rate!!!

http://www.lef.org/newshop/items/item00559.html

9. Taking extra Gamma E Tocopherol/Tocotrienols Vit E does not displace
alpha-tocopherol vit E. (from separate study not included with this
posting)

jackD

p.s Consider joining LEF Org just to get their magazine and high quality
supplement products at a discount. Great articles at this site.

http://www.lef.org

Life Sci. 2006 Mar 27;78(1 Cool

:2088-98. Epub 2006 Feb 3.

Tocotrienols: Vitamin E beyond tocopherols.

Sen CK, Khanna S, Roy S.

Department of Surgery, Davis Heart and Lung Research Institute, The Ohio
State University Medical Center, Columbus, Ohio 43210, USA.

In nature, eight substances have been found to have vitamin E activity:
alpha-, beta-, gamma- and delta-tocopherol; and alpha-, beta-, gamma- and
delta-tocotrienol. Yet, of all papers on vitamin E listed in PubMed less
than 1% relate to tocotrienols. The abundance of alpha-tocopherol in the
human body and the comparable efficiency of all vitamin E molecules as
antioxidants, led biologists to neglect the non-tocopherol vitamin E
molecules as topics for basic and clinical research. Recent developments
warrant a serious reconsideration of this conventional wisdom. Tocotrienols
possess powerful neuroprotective, anti-cancer and cholesterol lowering
properties that are often not exhibited by tocopherols. Current developments
in vitamin E research clearly indicate that members of the vitamin E family
are not redundant with respect to their biological functions.
alpha-Tocotrienol, gamma-tocopherol, and delta-tocotrienol have emerged as
vitamin E molecules with functions in health and disease that are clearly
distinct from that of alpha-tocopherol. At nanomolar concentration,
alpha-tocotrienol, not alpha-tocopherol, prevents neurodegeneration. On a
concentration basis, this finding represents the most potent of all
biological functions exhibited by any natural vitamin E molecule. An
expanding body of evidence support that members of the vitamin E family are
functionally unique. In recognition of this fact, title claims in
manuscripts should be limited to the specific form of vitamin E studied. For
example, evidence for toxicity of a specific form of tocopherol in excess
may not be used to conclude that high-dosage "vitamin E" supplementation may
increase all-cause mortality. Such conclusion incorrectly implies that
tocotrienols are toxic as well under conditions where tocotrienols were not
even considered. The current state of knowledge warrants strategic
investment into the lesser known forms of vitamin E. This will enable
prudent selection of the appropriate vitamin E molecule for studies
addressing a specific need.

Publication Types:
a.. Review

PMID: 16458936 [PubMed - indexed for MEDLINE]

Jack N Dalton · medicine forum beginner Joined: 22 Jun 2005 Posts: 7

Displacing Vit E Gamma by taking lots of alpha-tocopherol (AT) Vit E is
not a good for cardiovascular disease reasons as stated below.

jack n dalton

Nutr Rev. 2005 Aug;63( Cool

:290-3. Related Articles, Links

Failure of vitamin E in clinical trials: is gamma-tocopherol the answer?

Devaraj S, Jialal I.

Laboratory for Atherosclerosis and Metabolic Research, Department of
Pathology and Laboratory Medicine, University of California-Davis Medical
Center, Sacramento, USA.

Oxidative stress and inflammation play a crucial role in atherosclerosis.
However, prospective clinical trials of dietary antioxidants with
anti-inflammatory properties, such as alpha-tocopherol (AT), have not
yielded positive results. AT supplementation decreases gamma-tocopherol (GT)
levels. GT is an antioxidant with potent anti-inflammatory activity, and
plasma GT levels are inversely associated with cardiovascular diseases.
Thus, studies using pure GT, alone or in conjunction with AT, will elucidate
its utility in cardiovascular disease prevention.

Publication Types:
a.. Review

PMID: 16190316 [PubMed - indexed for MEDLINE]

"

Jack N Dalton · medicine forum beginner Joined: 22 Jun 2005 Posts: 7

Ann Intern Med. 2005 Jan 4;142(1):I40.

Meta-analysis: high-dosage vitamin E supplementation may increase all-cause
mortality.

Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar
E.

The Johns Hopkins School of Medicine, and The Welch Center for Prevention,
Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions,
Baltimore, Maryland 21205-2223, USA. ermiller@jhmi.edu

BACKGROUND: Experimental models and observational studies suggest that
vitamin E supplementation may prevent cardiovascular disease and cancer.
However, several trials of high-dosage vitamin E supplementation showed
non-statistically significant increases in total mortality. PURPOSE: To
perform a meta-analysis of the dose-response relationship between vitamin E
supplementation and total mortality by using data from randomized,
controlled trials. PATIENTS: 135,967 participants in 19 clinical trials. Of
these trials, 9 tested vitamin E alone and 10 tested vitamin E combined with
other vitamins or minerals. The dosages of vitamin E ranged from 16.5 to
2000 IU/d (median, 400 IU/d). DATA SOURCES: PubMed search from 1966 through
August 2004, complemented by a search of the Cochrane Clinical Trials
Database and review of citations of published reviews and meta-analyses. No
language restrictions were applied. DATA EXTRACTION: 3 investigators
independently abstracted study reports. The investigators of the original
publications were contacted if required information was not available. DATA
SYNTHESIS: 9 of 11 trials testing high-dosage vitamin E (> or =400 IU/d)
showed increased risk (risk difference > 0) for all-cause mortality in
comparisons of vitamin E versus control. The pooled all-cause mortality risk
difference in high-dosage vitamin E trials was 39 per 10,000 persons (95%
CI, 3 to 74 per 10,000 persons; P = 0.035). For low-dosage vitamin E trials,
the risk difference was -16 per 10,000 persons (CI, -41 to 10 per 10,000
persons; P > 0.2). A dose-response analysis showed a statistically
significant relationship between vitamin E dosage and all-cause mortality,
with increased risk of dosages greater than 150 IU/d. LIMITATIONS:
High-dosage (> or =400 IU/d) trials were often small and were performed in
patients with chronic diseases. The generalizability of the findings to
healthy adults is uncertain. Precise estimation of the threshold at which
risk increases is difficult. CONCLUSION: High-dosage (> or =400 IU/d)
vitamin E supplements may increase all-cause mortality and should be
avoided.

Publication Types:
a.. Meta-Analysis

"Jack N Dalton" <jdalton@ix.netcom.com> wrote in message
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M Dunne · medicine forum beginner Joined: 31 Jan 2006 Posts: 13

"Jack N Dalton" <jdalton@ix.netcom.com> wrote in message
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Jack N Dalton · medicine forum beginner Joined: 22 Jun 2005 Posts: 7

That is my whole point!!!

These IDIOTS (real ASSHOLES) have no idea that there is anything other than
d-alpha-tocopherol (AT) form of Vit E..

I must admit that it was Johns Hopkins that stated that maybe we were
looking at the wrong form of Vit E. Check that 2nd posting from them which I
posted first.

jack n dalton.

"M Dunne" <MarcusDunn@homsdffework.com> wrote in message
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