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Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils
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georgia
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PostPosted: Mon May 15, 2006 10:59 pm    Post subject: Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils Reply with quote
Infect Immun. 2005 Feb;73(2):1187-90. Related Articles, Links

Defective phagocytosis in Anaplasma phagocytophilum-infected
neutrophils.

Garyu JW, Choi KS, Grab DJ, Dumler JS.

Department of Pathology, Division of Medical Microbiology, The Johns
Hopkins
University School of Medicine, 720 Rutland Avenue, Ross 624, Baltimore,
MD
21205, USA.

Anaplasma phagocytophilum infection induces functional neutrophil
changes.
Using both Candida albicans and fluorescent-aggregate phagocytosis
assays,
we examined whether neutrophil and dimethyl sulfoxide-differentiated
HL-60
cell infection impairs internalization. A. phagocytophilum infection
significantly decreased phagocytosis compared to that of controls (P <
0.05). This further impairment of neutrophil function may promote
opportunistic infections and exacerbate disease.

PMID: 15664962 [PubMed - indexed for MEDLINE]
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