Paxil (paroxetine) increases the risk of suicidal behaviour in young adults.

john · medicine forum Guru Wannabe Joined: 23 Dec 2005 Posts: 186

http://www.pharmatimes.com/news/8880-GlaxoSmithKline-Paxil.aspx?src=PTDay

World News | FDA and GSK warn over Paxil suicide risk - 15/05/2006 The US
Food and Drug Administration and UK pharmaceutical giant GlaxoSmithKline
have sent a warning letter to healthcare professionals in the USA indicating
that its antidepressant Paxil (paroxetine) may increase the risk of suicidal
behaviour in young adults.

The move was spurred by the findings of a new analysis of clinical trial
data, which revealed that 11 patients out of 3,455 taking the drug tried to
commit suicide versus just one out of 1,978 in the placebo group.

The product's label will be updated to reflect the warning of an increased
risk of suicidal behaviour, but the company has urged caution over a sudden
change in treatment given that the evidence is centred on very small
percentages.

Paxil is certainly not new to safety scrutiny. The agent - which is sold as
Seroxat outside the USA - was recently linked to "major congenital
malformations" most commonly heart defects - in infants born to women who
took the drugs during the first trimester of pregnancy. And the drug has
already been associated with an increased risk of suicidal behaviour other
side of the pond.

Doctors in the UK were banned from prescribing Paxil and other
antidepressants in the selective serotonin reuptake inhibitor class to
children and adolescents, largely on the strength of the suicide data
released late last year. This debate has been widened to ask whether adults
are also affected.

Meanwhile, GSK suffered more bad news on the safety side when it emerged
that the use of its measles, mumps and rubella vaccine Priorix has been
suspended in Vietnam, pending an investigation into whether it caused the
death of an infant.

According to media reports, there has as yet been no confirmation whether
Priorix was administered to the child before it died, and Vietnamese
authorities have temporarily suspended the use of all MMR vaccines as a
precautionary measure.

Rick Morris · medicine forum addict Joined: 11 May 2005 Posts: 91

The risk of suicide after starting an anti-depressant has been around as
long as anti-depressants. It is a testament to the medications ability to
lift moods, unfortunately in these cases enough to gather strength to carry
out their suicide. I suggest that someone do a study on anti-depressants
with non-depressed subjects and see if they get the same results. It is
well documented that depressed people are already

--
To forget one's purpose is the commonest form of stupidity.

Friedrich Nietzsche
at higher risk to attempt suicide.

On 5/15/06 9:42 AM, in article CqKdnc1cuLTTDvXZRVnyiw@bt.com, "john"
<scu23@btinternet.com> wrote:

john · medicine forum Guru Wannabe Joined: 23 Dec 2005 Posts: 186

"Rick Morris" <wmorris@neb.rr.com> wrote in message
news:C08E2634.F7F8%wmorris@neb.rr.com...

Rick Morris · medicine forum addict Joined: 11 May 2005 Posts: 91

I am not so interested in the Isotretinoin study as it is not paroxetine nor
is it known to be an SSRI. If you have the studies on the use of paroextine
on non-depressed individuals, please forward them to me via the
sci.med.nursing newsgroup.

Bottom line here is that is more than likely the successful effect of
paroxetine that leads young people to a state of having enough energy to
attempt suicide.

Again, this is 30 year old news as far as anti-depressants go.

--
To forget one's purpose is the commonest form of stupidity.

Friedrich Nietzsche

On 5/16/06 2:19 AM, in article -o2dnUSHI-dr4fTZnZ2dnUVZ8qSdnZ2d@bt.com,
"john" <scu23@btinternet.com> wrote:

Google