Acid reflux / lecithin

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

[Effects of phosphatidylcholine pretreatment during acute experimental
biliary reflux]
Eros G, Kaszaki J, Czóbel M, Boros M
Magy Seb. 2005 Dec ; 58(6): 406-14

Biliary regurgitation plays important role in gastro-esophageal reflux
disease and postoperative complications. Our major aims were to find
out the consequences of short-term exposure with luminal bile on
mucosal microcirculation and nitric oxide synthesis, and to determine
the effects of systemic phosphatidylcholine pretreatment in this
condition. The experiments were performed on inbred mongrel dogs. Group
1 (n=5) served as a saline-treated control, while in group 2 (n=5) the
esophagus was exposed to bile for 3 h. In group 3 (n=5) the animals
were pre-treated with 7-nitroindazole (7-NI), to inhibit the neuronal
isoform of nitric oxide synthase. In group 4 (n=5) phosphatidylcholine
(PC) solution (50 mg/kg) was administered iv before the biliary
challenge. The microcirculation of the mucosa was observed by
intravital videomicroscopy; myeloperoxidase and nitric oxide synthase
activities, the degree of mast cell degranulation and tissue damage
were evaluated via tissue biopsies. Exposure to bile evoked significant
mast cell degranulation and leukocyte accumulation, and the red blood
cell velocity (VRBC) and the diameter of the postcapillary venules (VD)
increased significantly. The tissue ATP content and constitutive nitric
oxide synthase activity decreased, while the inducible nitric oxide
synthase activity increased significantly as compared with the control
values. 7-NI treatment significantly exacerbated the mucosal mast cell
degranulation and tissue damage. In contrast, PC pretreatment reversed
the bile-induced ATP depletion, the inducible nitric oxide synthase and
myeloperoxidase activity increases, and the mast cell degranulation.
CONCLUSIONS: The neuronal nitric oxide synthase--mast cell axis plays
an important role in the esophageal mucosal defense system. Systemic PC
pretreatment affords effective protection through ameliorating the
bile-induced ATP depletion and secondary inflammatory reaction.

-----------------------------------------------------------------------------------------------------------
Which goes right along with the article below .. remission in 50% of
patients.
-----------------------------------------------------------------------------------------------------------

Retarded release phosphatidylcholine benefits patients with chronic
active ulcerative colitis.
Stremmel W, Merle U, Zahn A, Autschbach F, Hinz U, Ehehalt R
Gut. 2005 Jul ; 54(7): 966-71

BACKGROUND AND AIMS: We examined the hypothesis of an anti-inflammatory

effect of phosphatidylcholine in ulcerative colitis.
METHODS:
A phase IIA, double blind, randomised, placebo controlled study was
performed
in 60 patients with chronic active, non steroid dependent, ulcerative
colitis, with a clinical activity index (CAI) of > or = 4. Retarded
release phosphatidylcholine rich phospholipids and placebo were
administered at a dose of 6 g daily over three months. The primary end
point was a change in CAI towards clinical remission (CAI < or = 3) or
CAI improvement by > or = 50%. Secondary end points included > or = 50%

changes in endoscopic activity index (EAI), histology, and quality of
life scores.
RESULTS: Induction of clinical remission (CAI < or = 3) as
the primary outcome variable was attained by 16 (53%) patients in the
phosphatidylcholine treated group compared with three (10%) in the
placebo group (p<0.00001). The rate of clinical remission and CAI
improvement was 90% in the phosphatidylcholine group and only 10% in
the placebo group. A median drop of seven points in the CAI score (70%
improvement) was recorded in the phosphatidylcholine group compared
with no change in the placebo group. Secondary end point analysis
revealed concomitant drops in EAI and histology scores (p = 0.00016 and

p = 0.0067 compared with placebo, respectively). Improvement in quality

of life was reported by 16 of 29 evaluated patients in the
phosphatidylcholine group compared with two of 30 in the placebo group
(p = 0.00005).
CONCLUSION: Retarded release oral phosphatidylcholine is
effective in alleviating inflammatory activity caused by ulcerative
colitis.

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Tom

Jesus Was A Vegetarian!
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Neryl Chyphes · medicine forum beginner Joined: 11 Mar 2006 Posts: 47

Well Tom, I don't see what this has to do with iron?

Are you trying to suggest a link between leaky gut and the 1001 problems which
some people associate with iron?

Is phosphatidylcholine the saviour?

N.

<ironjustice@aol.com> wrote in message news:1147301437.998296.134750@v46g2000cwv.googlegroups.com...
[Effects of phosphatidylcholine pretreatment during acute experimental
biliary reflux]
Eros G, Kaszaki J, Czóbel M, Boros M
Magy Seb. 2005 Dec ; 58(6): 406-14

Biliary regurgitation plays important role in gastro-esophageal reflux
disease and postoperative complications. Our major aims were to find
out the consequences of short-term exposure with luminal bile on
mucosal microcirculation and nitric oxide synthesis, and to determine
the effects of systemic phosphatidylcholine pretreatment in this
condition. The experiments were performed on inbred mongrel dogs. Group
1 (n=5) served as a saline-treated control, while in group 2 (n=5) the
esophagus was exposed to bile for 3 h. In group 3 (n=5) the animals
were pre-treated with 7-nitroindazole (7-NI), to inhibit the neuronal
isoform of nitric oxide synthase. In group 4 (n=5) phosphatidylcholine
(PC) solution (50 mg/kg) was administered iv before the biliary
challenge. The microcirculation of the mucosa was observed by
intravital videomicroscopy; myeloperoxidase and nitric oxide synthase
activities, the degree of mast cell degranulation and tissue damage
were evaluated via tissue biopsies. Exposure to bile evoked significant
mast cell degranulation and leukocyte accumulation, and the red blood
cell velocity (VRBC) and the diameter of the postcapillary venules (VD)
increased significantly. The tissue ATP content and constitutive nitric
oxide synthase activity decreased, while the inducible nitric oxide
synthase activity increased significantly as compared with the control
values. 7-NI treatment significantly exacerbated the mucosal mast cell
degranulation and tissue damage. In contrast, PC pretreatment reversed
the bile-induced ATP depletion, the inducible nitric oxide synthase and
myeloperoxidase activity increases, and the mast cell degranulation.
CONCLUSIONS: The neuronal nitric oxide synthase--mast cell axis plays
an important role in the esophageal mucosal defense system. Systemic PC
pretreatment affords effective protection through ameliorating the
bile-induced ATP depletion and secondary inflammatory reaction.

-----------------------------------------------------------------------------------------------------------
Which goes right along with the article below .. remission in 50% of
patients.
-----------------------------------------------------------------------------------------------------------

Retarded release phosphatidylcholine benefits patients with chronic
active ulcerative colitis.
Stremmel W, Merle U, Zahn A, Autschbach F, Hinz U, Ehehalt R
Gut. 2005 Jul ; 54(7): 966-71

BACKGROUND AND AIMS: We examined the hypothesis of an anti-inflammatory

effect of phosphatidylcholine in ulcerative colitis.
METHODS:
A phase IIA, double blind, randomised, placebo controlled study was
performed
in 60 patients with chronic active, non steroid dependent, ulcerative
colitis, with a clinical activity index (CAI) of > or = 4. Retarded
release phosphatidylcholine rich phospholipids and placebo were
administered at a dose of 6 g daily over three months. The primary end
point was a change in CAI towards clinical remission (CAI < or = 3) or
CAI improvement by > or = 50%. Secondary end points included > or = 50%

changes in endoscopic activity index (EAI), histology, and quality of
life scores.
RESULTS: Induction of clinical remission (CAI < or = 3) as
the primary outcome variable was attained by 16 (53%) patients in the
phosphatidylcholine treated group compared with three (10%) in the
placebo group (p<0.00001). The rate of clinical remission and CAI
improvement was 90% in the phosphatidylcholine group and only 10% in
the placebo group. A median drop of seven points in the CAI score (70%
improvement) was recorded in the phosphatidylcholine group compared
with no change in the placebo group. Secondary end point analysis
revealed concomitant drops in EAI and histology scores (p = 0.00016 and

p = 0.0067 compared with placebo, respectively). Improvement in quality

of life was reported by 16 of 29 evaluated patients in the
phosphatidylcholine group compared with two of 30 in the placebo group
(p = 0.00005).
CONCLUSION: Retarded release oral phosphatidylcholine is
effective in alleviating inflammatory activity caused by ulcerative
colitis.

Abstract · PubMed · FullText · SFX · LF+ · GS · Order · Clip ·
Citation · BibTeX · Related · TouchGraph · Scopus · References ·
Tag
tags: annotation:

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Neryl Chyphes · medicine forum beginner Joined: 11 Mar 2006 Posts: 47

<ironjustice@aol.com> wrote in message news:1147308697.376913.249490@j73g2000cwa.googlegroups.com...

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

http://tinyurl.com/mfpsw

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

University of Toronto scientist Lilian Thompson made unleavened bread
from navy bean flour and fed it to 10 healthy volunteers, with and
without the bean's normal levels of phytic acid. Bread without the
phytic acid induced 52% higher blood-glucose responses.

http://www.herbalgram.org/iherb/herbalgram/articleview.asp?a=841

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

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