Diet / bloodletting / iron chelators / insulin

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

So I wonder if .. NOW .. a 'low iron diet' .. is .. suggested .. ?

<<snip>>
insulin resistance significantly decreased after diet, and a further
reduction was observed after phlebotomies. Iron depletion by
desferrioxamine increased by twofold the (125)I-insulin-specific
binding, whereas iron addition reduced insulin binding
<<snip>>

Aliment Pharmacol Ther. 2005 Nov;22 Suppl 2:61-3. Links

Iron and insulin resistance.

Fargion S, Dongiovanni P, Guzzo A, Colombo S, Valenti L, Fracanzani AL.

Dipartimento Medicina Interna, Ospedale Maggiore IRCCS, Universita di
Milano, Milano, Italy.

Background : Preliminary clinical and experimental results suggest that

iron can modify hepatocytes' insulin sensitivity by interfering with
insulin receptor and intracellular insulin signalling. Aim : To
evaluate in vivo the influence of iron on insulin resistance and
insulin release in patients with non-alcoholic fatty liver disease and
in vitro the interaction between iron and insulin sensitivity by
analysing the effect of iron manipulation on insulin receptor
expression in hepatoblastoma HepG2 cell line. Results : Insulin
resistance evaluated by homeostatis model assessment (HOMA)-insulin
resistance significantly decreased after diet, and a further reduction
was observed after phlebotomies. Iron depletion by desferrioxamine
increased by twofold the (125)I-insulin-specific binding, whereas iron
addition reduced insulin binding, similarly to cells exposed to high
glucose concentration. Conclusion : Iron status affects insulin
sensitivity by modulating the transcription and membrane
expression/affinity of insulin receptor expression in hepatocytes and
influencing insulin-dependent gene expression suggesting that increased

insulin clearance and decreased insulin resistance may contribute to
the positive effect of iron depletion in patients with non-alcoholic
fatty liver disease.

PMID: 16225476 [PubMed - in process]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

outsor@citynet.net · medicine forum Guru Joined: 11 Sep 2005 Posts: 569

"So I wonder if .. NOW .. a 'low iron diet' .. is .. suggested .. ?"

Looks like it could be for these folk:

"patients with non-alcoholic fatty liver disease."

But it says nothing about having that specific disorder and doesn't
support the iron causes all disease because people eat meat idea.

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Let me be more .. precise ..

B-I-L-L-I-O-N-S .. of .. people ..

http://www.findarticles.com/p/articles/mi_m0FDN/is_4_7/ai_91155401

NAFLD is known to affect 10-39 percent of the general global population
with an average incidence of 20 percent. (5,6) It is the most common
cause of increased liver enzyme levels in adults in the United States.
(7) NAFLD occurs commonly in diabetics and the obese: 50 percent of
diabetics (ranging between 21 and 78 percent), 57-74 percent of obese
persons, (5) and 90 percent of morbidly obese persons (over 200 percent
of ideal body weight) ( Cool

are affected.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

outsor@citynet.net · medicine forum Guru Joined: 11 Sep 2005 Posts: 569

Bringing the focus back to the underlying question, does iron cause fatty
liver disease or is its level an effect of it? It doesn't help the
ironcauses all disease because people eat meat idea. Many millions of
people in countries where few or no animal products are eaten have the
highest levels of diabetes and one presumes higher risk for this disorder.

This is yet
another nail in the coffin where only one counter example is required to
toss an idea.

Google